Genetic Testing

Welcome to PureGenomics™
Within every patient’s genome are opportunities to optimize health and wellness. Genetic testing can empower practitioners with information that can enhance patient management and clinical outcomes. But the translation of genetic testing to effective clinical decisions can be challenging.
PureGenomics™ is a platform combining educational tools, protocols and core products with our dynamic, practitioner-exclusive website application designed to help identify common genetic variations known as Single Nucleotide Polymorphisms (SNPs) that are clinically relevant and nutritionally actionable. This unique platform makes it easy to TEST, TRANSLATE and TARGET SNPs with the right nutritional support, empowering practitioners with precision and confidence in the pursuit of optimal health for every patient.

 

Seek New Potential
PureGenomics™  is a physician-exclusive website application, that we have registered with to provide you access to the patient portal.
PureGenomics™ identifies common genetic variations known as Single Nucleotide Polymorphisms (SNPs) that are clinically relevant and nutritionally actionable.  This unique platform makes it easy to TEST, TRANSLATE and TARGET SNPs with the right nutritional support, empowering practitioners with precision and confidence in the pursuit of optimal health for every patient.

 

    • TEST for nutritionally relevant SNPs with saliva-based personal genome analysis kits by 23andMe® , a personal genomics and biotechnology company. Simply visit www.23andMe.com, order the kit and follow the step-by-step instructions to obtain full-service genotyping and secure, downloadable results.​
    • TRANSLATE results to nutritional recommendations with www.PureGenomics.ca. This innovative website application:
      1. Receives the 23andMe® results
      2. Identifies well-researched, clinically relevant, actionable SNPs
      3. Translates results into specific recommendations

  • TARGET with personalized nutritional support. Pure Encapsulations’ PureGenomics™ platform of products provides specialized support with targeted ingredients at clinically relevant doses, and in clinically relevant forms. Developed in collaboration with Nathan Morris, M.D.† and Kelly Heim, Ph.D., PureGenomics™ empowers you with the knowledge and products needed to bring personalized nutrition to a higher level of precision. Learn which gene variations exist for each patient, and make rational, individualized supplement decisions with confidence.
What are Single Nucleotide Polymorphisms (SNPs)?

The genes that encode different enzymes, such as MTHFR and MTR, are prone to common mutations, or SNPs, many of which affect the entire methylation balance. These SNPs change the gene’s “instruction manual,” encoding a protein with altered shape, activity, stability and/ or abundance (Figures 1-2).

More than half of the population has SNPs that reduce the activity of one or more enzymes by up to 70%. Several SNPs directly affect nutrient assimilation and response to supplementation. A targeted nutritional approach is the most effective way to address these common variations.

 

Figure 1:

The C677T SNP in the MTHFR enzyme is one of the most common SNPs. Like other SNPs, it is a mutation of a single “letter” in the gene sequence. In this example, the C (cytosine) is mutated to a T (thymidine). This reduces the enzyme activity by up to 70%.

Figure 2:

SNPs often alter the shape and/or reduce the function of enzymes. Rarely, SNPs can improve the function of enzymes (not shown).

How to get started:
  1. phone or email me to get signed up with PureGenomics™.
  2. I will send you a PureGenomics™ email invitation with a link to register for an account.​
  3. Visit ​www.23andme.com/en-ca/ to purchase a genetic test kit.
  4. When you receive the kit, follow the step-by-step instructions provided.​
  5. You will receive an email from 23andMe® when your results are ready
  6. Once your results are received, log into your PureGenomics™ account, select “Connect with 23andMe®”. PureGenomics™ will automatically sync with your 23andMe® raw data. The information will populate in my through Allyson O’Brien Nutrition & Advanced Aesthetics account.
  7. Book an appointment to review your results with myself!